Outstanding research - New Article in Nature

Posted on April 05, 2019

Outstanding Research - Detection of Transcriptomic Changes in B-cell Lymphoma

Burkitt lymphoma is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), Dr. Gero Doose, our head of research and development, performed transcriptome sequencing data analysis of 39 sporadic Burkitt lymphoma. Dr. Doose and colleagues unraveles the interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation.

López C, Kleinheinz K, Aukema SM, Rohde M, Bernhart SH, Hübschmann D, Wagener R, Toprak UH, Raimondi F, Kreuz M, Waszak SM, Huang Z, Sieverling L, Paramasivam N, Seufert J, Sungalee S, Russell RB, Bausinger J, Kretzmer H, Ammerpohl O, Bergmann AK, Binder H, Borkhardt A, Brors B, Claviez A, Doose G, Feuerbach L, Haake A, Hansmann ML, Hoell J, Hummel M, Korbel JO, Lawerenz C, Lenze D, Radlwimmer B, Richter J, Rosenstiel P, Rosenwald A, Schilhabel MB, Stein H, Stilgenbauer S, Stadler PF, Szczepanowski M, Weniger MA, Zapatka M, Eils R, Lichter P, Loeffler M, Möller P, Trümper L, Klapper W; ICGC MMML-Seq Consortium, Hoffmann S, Küppers R, Burkhardt B, Schlesner M, Siebert R.: 'Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma.'. Nature Communications, 10.1038/s41467-019-08578-3 (2019)

Dr. Gero Doose
Dr. Gero Doose is head of research and development at ecSeq Bioinformatics GmbH. He developed RNA folding and protein solubility prediction algorithms before he started working with high-throughput sequencing data. Gero implemented detection pipelines for circularized and trans-spliced transcripts. As an expert for split-read alignment analysis, he also developed a sophisticated method to detect differential alternative splicing.

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